Ioannides AS, Henderson DJ, Spitz L, Copp AJ.
Neural Development Unit and the Surgery Unit, Institute of Child Health, University College London, and the Institute of Human Genetics, University of Newcastle, England.
J Pediatr Surg. 2003 Jan;38(1):29-36.
The secreted glycoprotein, Sonic hedgehog (Shh) plays an important patterning role in the development of many organ systems. The authors aimed to study the temporal and spatial pattern of expression of Shh and its receptor Ptc1 during the development of the anterior foregut and to test the hypothesis that the Shh expression pattern is disturbed during the development of oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF) in Adriamycin-treated mouse embryos.