Spilde T, Bhatia A, Ostlie D, Marosky J, Holcomb G 3rd, Snyder C, Gittes G.
Department of Surgery, The Laboratory for Surgical Organogenesis, Children's Mercy Hospital, Kansas City, MO.
J Pediatr Surg. 2003 Mar;38(3):465-8.
Many theories of the pathogenesis of esophageal atresia with tracheoesophageal fistula (EA/TEF) have been proposed, but no specific mechanism has been demonstrated. The authors previously reported data suggesting a respiratory origin of the fistula tract in the rat model and in humans. Sonic hedgehog (Shh) "knockout" mice have the VACTERL association, and thus it was hypothesized that defects in Shh signaling may exist in the human neonatal EA/TEF fistula tract.